Page 4 of 7 SODIUM PHOSPHATES Injection, USP 45 mM P in 15 mL (3 mM P and 4 mEq Na +/mL) FOR ADDITIVE USE ONLY AFTER DILUTION IN I.V. o phosphorus 6.4 mmol/100 mL (potassium 10 mEq/100 mL) for peripheral administration o phosphorus 18 mmol/100 mL (potassium 28.2 mEq/100mL) for central administration • Visually inspect the solution for particulate matter and discoloration before and after dilution and prior to administration. It is also not known whether sodium phosphate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Sodium Phosphates Injection, USP, 3 mmol/mL (millimoles/mL), is a sterile, nonpyrogenic, Intravenously infused phosphate not taken up by the tissues is excreted almost entirely in the urine. Tissue loading may occur at even lower rates of administration. The toolkit offers seven modules, including an introduction outlining the objectives for each topic in the series. • Phosphate replacement must be ordered in mmol of phosphorus. Formula to convert mEq/L values to mmol/L Sodium , is 1 mEq/L is equivalent to 1.0 mmol/L . Potassium Phosphate Each mL of potassium phosphate contains 4.4 milliequivalents (mEq) of potassium and 3 millimoles (mmol) of phosphate. How many mEq of Na+ would be contained in a 30 mL dose of the following solution? The suggested dose of phosphorus for infants receiving TPN is 1.5 to 2 mmol/kg/day. Note: Fill in one box to get results in the other box by clicking "Calculate" button. Serum sodium, inorganic phosphorus and calcium levels should be monitored as a guide to dosage. Sodium ions and phosphorus ions are known to be substantially excreted by the kidney, and the risk of toxic reactions may be greater in patients with impaired renal function. If the person weighs 60 kg, how many milliliters of 0.9 % sodium chloride sterile solution should be administered? In the event of overdosage, discontinue infusions containing sodium phosphate immediately and institute corrective therapy to restore depressed serum calcium and to reduce elevated serum sodium levels. sodium (Na +) 150 mmol (150 mEq) per litre chloride (Cl –) 150 mmol (150 mEq) per litre. To calculate just use formula 1.0 mEq/L * mmol/L Caution must be exercised in the administration of parenteral fluids especially those containing sodium ion, to patients receiving corticosteroids or corticotropin. 3 mmol Phosphate/mL and 4.4 mEq Potassium/mL. FOR ADDITIVE USE ONLY AFTER DILUTION IN IV FLUIDS. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. (adsbygoogle = window.adsbygoogle || []).push({}); Formula to convert mEq/L values to mmol/L Sodium , is 1 mEq/L is equivalent to 1.0 mmol/L . The most reliable method of ordering IV phosphate is by millimoles, then specifying the potassium or sodium salt. 43-) for addition to large volume infusion fluids for intravenous use. Enema: Sodium phosphate 6 g and sodium biphosphate 16 g/100 mL (67.5 mL pediatric enema unit, 135 mL adult enema unit) Injection: Phosphate 3 mmol and sodium 4 mEq per mL (5 mL, 10 mL, 15 mL, 30 mL, 50 mL) Solution, oral: Sodium phosphate 18 g and sodium biphosphate 48 g/100 mL (45 mL, 90 mL, 273 mL) Meq is used to quantify implications with electrolytes. An evaluation of current literature revealed no clinical experience identifying differences in response between elderly and younger patients. 3 mmol P and 4 mEq Na + / mL. Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. PRECAUTIONS and For further information about unapproved drugs, click here. Occurs as a colorless or white granular salt freely soluble in water. You do not have to view each module in order; however, the Global Impact of Sodium on Health module is recommended as a starting point following the Introduction. Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. [1 packet equivalent to elemental phosphorus 250 mg (~8 mmol), sodium 164 mg (7.1 mEq), and potassium 278 mg (7.1 mEq) per packet]. Phosphate intoxication results in a reduction of serum calcium and the symptoms are those of hypocalcemic tetany (see The solution is administered after dilution by the … Sodium phosphate is contraindicated in diseases where high phosphate or low calcium levels may be encountered, and in patients with hypernatremia. The solution contains a mixture of both potassium phosphate monobasic (KH 2 PO 4 ) and potassium phosphate dibasic (K 2 HPO 4 ). Phosphate in the extracellular fluid is primarily in inorganic form and plasma levels may vary somewhat with age. Phosphorus preparations [8] 1 mmol of potassium phosphate contains ∼ 1.5 mEq of potassium. Molecular weight of NaCl = 58.5 mg= ë, å, â å ℎ ç Total mEq required= 2 x 60= 120 mEq DESCRIPTION. When serum sodium concentration is low, the secretion of antidiuretic hormone (ADH) by the pituitary is inhibited, thereby preventing water reabsorption by the distal renal tubules. Each mL provides 3 mmol of phosphorus and 4 mEq sodium. In patients on TPN, approximately 10 to 15 mmol of phosphorus (equivalent to 310 to 465 mg elemental phosphorus) per liter bottle of TPN solution is usually adequate to maintain normal serum phosphate, though larger amounts may be required in hypermetabolic states. It contains no bacteriostat, antimicrobial agent or added buffer. Reduce the dose by 50% in patients with impaired renal function who are not on hemodialysis. 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